Diagnostic tests projects

Early detection is important to reduce transmission, but also because it reduces the risk of permanent impairments. LRI supports studies which aim to develop and test new assays for diagnosis of disease and infection.

 

<< Supported projects

 

 

 

 

ONGOING PROJECTS

 

Describing metabolic profiles

Project coordination

Emory University School of Medicine (USA)

Country

Brazil

 

There are many knowledge gaps surrounding leprosy transmission, diagnostics and morbidity management.This research project will study  the interaction between the host (humans) and the pathogen (Mycobacterium leprae) by looking for “metabolic signatures” using innovative methods.

 

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Biomarkers for early detection

Project coordination

Maharaja Sayajirao University of Baroda (India)

Countries

India, USA

 

How can some infected people resist an infection with the leprosy baceria while others develop the disease? This project aims to better understand this question.

 

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Novel interventions and diagnostic tests for leprosy

Project coordination

Erasmus MC, University Medical Center and Leiden University Medical Center (Netherlands)

Country

Netherlands, Bangladesh

 

Through detection of infected individuals and subsequent prophylactic treatment the researchers aim to be able to avoid leprosy ever becoming manifest in their lives.

 

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Mycobacterium leprae molecular viability assays

Project coordination

National Hansen's Disease Program (USA)

Country

Nepal, Ethiopia, Phillipines, USA

 

Discerning the difference between live and dead bacteria is the most fundamental procedure in microbiology and has been one of the primary obstacles impeding research in leprosy. Our inability to easily culture M. leprae and determine its viability makes monitoring the progress of treatment in patients challenging and limits our ability to design improved drug therapy regimens and chemoprophylaxis programs.

 

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Functional analysis of candidate variants in the early-onset leprosy

Project coordination

Pontifical Catholic University of Parana, Brazil (PUCPR)

Country

Brazil

 

Two variants in the LRRK2 gene were found to be strong candidates to control leprosy susceptibility in a unique family affected by leprosy. By infecting macrophages in vitro with M. leprae, this genetic susceptibility will be further studied.

 

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Integration of rapid diagnostic tests

Project coordination

Infectious Disease Research Institute (USA)

Country

Philippines

 

Detection and management of leprosy cases currently relies heavily on examination by expert clinicians. This requirement significantly limits the scope, reach, efficiency and even feasibility of surveillance. This study evaluates if certain antibody tests could to serve as a simple, quantifiable and robust measurement to facilitate referral for expert clinical exam.

 

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