Diagnostic tests projects
Early detection is important to reduce transmission, but also because it reduces the risk of permanent impairments. LRI supports studies which aim to develop and test new assays for diagnosis of disease and infection.
Describing metabolic profiles
Emory University School of Medicine (USA)
There are many knowledge gaps surrounding leprosy transmission, diagnostics and morbidity management.This research project will study the interaction between the host (humans) and the pathogen (Mycobacterium leprae) by looking for “metabolic signatures” using innovative methods.
Biomarkers for early detection
Maharaja Sayajirao University of Baroda (India)
How can some infected people resist an infection with the leprosy baceria while others develop the disease? This project aims to better understand this question.
Novel interventions and diagnostic tests for leprosy
Erasmus MC, University Medical Center and Leiden University Medical Center (Netherlands)
Through detection of infected individuals and subsequent prophylactic treatment the researchers aim to be able to avoid leprosy ever becoming manifest in their lives.
Mycobacterium leprae molecular viability assays
National Hansen's Disease Program (USA)
Nepal, Ethiopia, Phillipines, USA
Discerning the difference between live and dead bacteria is the most fundamental procedure in microbiology and has been one of the primary obstacles impeding research in leprosy. Our inability to easily culture M. leprae and determine its viability makes monitoring the progress of treatment in patients challenging and limits our ability to design improved drug therapy regimens and chemoprophylaxis programs.
Functional analysis of candidate variants in the early-onset leprosy
Pontifical Catholic University of Parana, Brazil (PUCPR)
Two variants in the LRRK2 gene were found to be strong candidates to control leprosy susceptibility in a unique family affected by leprosy. By infecting macrophages in vitro with M. leprae, this genetic susceptibility will be further studied.
Integration of rapid diagnostic tests
Infectious Disease Research Institute (USA)
Detection and management of leprosy cases currently relies heavily on examination by expert clinicians. This requirement significantly limits the scope, reach, efficiency and even feasibility of surveillance. This study evaluates if certain antibody tests could to serve as a simple, quantifiable and robust measurement to facilitate referral for expert clinical exam.