Disability projects

Disability is not only about physical dysfunction but has a broader scope, including stigma, discrimination, and social participation restrictions. Important underlying causes of physical dysfunction include neural and ocular impairments. The LRI therefore supports research that can contribute to preventing or lessening the burden of disability, including the investigation of new treatment options, risk factors and detection of nerve function impairment, preventive interventions and prevalence surveys. Other NTDs may be included alongside leprosy.

 

<< Supported projects

 

 

 

 

ONGOING PROJECTS

 

Two randomised controlled trials in ENL

Project coordination

London School of Hygiene Tropical Medicine

Country

Bangladesh, India, Indonesia, Nepal, Philippines, Ethiopia, Brazil

 

Erythema nodosum leprosum (ENL) is a severe and extremely painful complication of leprosy which can occur before, during or after completion of antibacterial treatment. This study conducts two randomised controlled trials in several countries to test the effectiveness of methotrexate, which might provide a better option than current treatment methods.

 

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Patient self-monitoring to detect nerve function impairment

Project coordination

Leonard Wood Memorial Center for Leprosy Research (Philippines)

Country

Phillipines

 

This study aims to assess whether skin lesions can be used as proxy indicaor to detect early signs of nerve function impairment in leprosy.

 

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Management of Erythema Nodosum Leprosum

Project coordination

VU University Amsterdam, Athena Institute (The Netherlands)

Country

Indonesia, India

 

Leprosy reactions are serious complications of leprosy which lead to impairment, disability and for instance pain. Treatment of leprosy reactions is available, but individuals with reactions experience often adverse effects.This research project evaluates how the management of leprosy reactions may be improved by including the perspectives of affected persons and taking a participatory approach.

 

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M-Health to motivate self-care

Project coordination

The Schieffelin Institute of Health Research & Leprosy Centre

Country

India

 

In this project a personalised link with patients will be established through a common cost effective technological platform to influence and help the adherence to the treatment, monitoring and follow up of these patients. Effective IEC strategies for leprosy affected patients will be identified.

 

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Design of Customized Offloading Devices

Project coordination

Schieffelin Institute of Health Research & Leprosy Centre

Country

India

 

Patients suffering from nerve damage caused by leprosy can have a loss of sensation in the feet, which leads to wounds on the sole of the foot. Non-infected simple ulcers are usually treated with total contact casts, which are heavy. This project develops and tests alternative lightweight devices with the help of computer software.

 

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Identification of leprosy associated immune signatures

Project coordination

The Schieffelin Institute of Health-Research and Leprosy Centre (India)

Country

India

 

This study uses molecular biology techniques to develop a laboratory test for early diagnosis of type I en type II reactions in leprosy.

 

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Family-care groups for self-management of leprosy, podoconiosis and lympatic filariasis related disabilities

Project coordination

Ethiopian National Association of People Affected by Leprosy (ENAPAL)

Country

Ethiopia

 

This project explores family-based approaches aimed at prevention and sustainable self-management of disabilities due to leprosy, podoconiosis and lymphatic filariasis.

 

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Helminths influences in leprosy

Project coordination

The Leprosy Mission Nepal

Country

Nepal

 

This study investigates if worm infection or deworming has any relevance to leprosy clinical care. The research group aims to detect risks and associations between helminth indicators, leprosy indicators and clinical outcomes including leprosy reaction development, severity and duration.

 

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