Interrupt transmission projects
The ultimate goal of leprosy control services is to interrupt the transmission of leprosy. Current approaches to case detection and treatment with MDT have not led to a sufficient decrease in incidence of leprosy in many countries or areas within countries. Recent research has shown that strategies aim at contacts of leprosy patients are the most promising and cost-effective options to further reduce the incidence of leprosy.
Therefore, the LRI supports implementation research aimed at introducing or scaling up effective contact management or chemoprophylaxis interventions. Testing of additional contact examination interventions, chemoprophylaxis regimen or other prophylaxis approaches, such as immune-prophylaxis, are eligible for support. Studies aimed at reducing or removing barriers to the effective use of contact-based interventions are also eligible for support.
PEOPLE: Post ExpOsure Prophylaxis for LEprosy
Institute of Tropical Medicine (ITG), Belgium
This is a “cluster randomized” trial on effectiveness of different modalities of Single Double Dose of Rifampicin Post-Exposure Prophylaxis (SDDR-PEP) for leprosy in the Comoros (Anjouan and Mohéli) and Madagascar.
Molecular mechanisms controlling human susceptibility to leprosy
Pontifícia Universidade Católica do Paraná
In this project, the research group proposes to apply next-generation sequencing technology to sequence six genes consistently associated with host susceptibility to leprosy and leprosy reactions.
Mozambique, Ehtiopia, Tanzania
The aim of the PEP4LEP study is to contribute to interrupting the transmission of M. leprae by identifying the most effective and feasible method of screening people at risk of developing leprosy and administering chemoprophylaxis in Ethiopia, Mozambique and Tanzania.
Mycobacterium leprae molecular viability assays
National Hansen's Disease Program (USA)
Nepal, Ethiopia, Phillipines, USA
Discerning the difference between live and dead bacteria is the most fundamental procedure in microbiology and has been one of the primary obstacles impeding research in leprosy. Our inability to easily culture M. leprae and determine its viability makes monitoring the progress of treatment in patients challenging and limits our ability to design improved drug therapy regimens and chemoprophylaxis programs.
Novel interventions and diagnostic tests for leprosy
Erasmus MC, University Medical Center and Leiden University Medical Center (Netherlands)
Through detection of infected individuals and subsequent prophylactic treatment the researchers aim to be able to avoid leprosy ever becoming manifest in their lives.