Nerve function impairment and reactions projects
Neural and ocular impairments and disabilities are the main causes behind the many problems persons affected by leprosy may experience.
The LRI therefore supports studies of approaches and interventions for primary prevention of nerve or ocular damage, methods to improve detection and interventions and treatment regimen to improve the prognosis of NFI and leprosy reactions.
LepVax: Leprosy Vaccine Trail, Phase 1b
American Leprosy Missions (ALM)
LepVax, a defined subunit vaccine designed specifically for leprosy, has cleared safety evaluations in healthy volunteers in the United States. This proposal supports the onward clinical development of the LepVax by conducting a Phase 1b/2a randomized, placebo-controlled, clinical trial in Brazil.
Treatment of erythema nodosum leprosum
London School of Hygiene and Tropical Medicine (UK)
Bangladesh, Brazil, Ethiopia, India, Indonesia, Nepal, the Philippines
Erythema nodosum leprosum (ENL) is an immunological complication affecting individuals with lepromatous leprosy. It is estimated that over 50,000 of the new leprosy patients diagnosed each year are at risk of ENL. The inflammatory state of ENL causes significant morbidity and if untreated mortality. In this project the efficacy of methotrexate is assessed in the managment of ENL.
Management of Erythema Nodosum Leprosum
VU University Amsterdam, Athena Institute (The Netherlands)
Leprosy reactions are serious complications of leprosy which lead to impairment, disability and for instance pain. Treatment of leprosy reactions is available, but individuals with reactions experience often adverse effects.This research project evaluates how the management of leprosy reactions may be improved by including the perspectives of affected persons and taking a participatory approach.
Identification of leprosy associated immune signatures
The Schieffelin Institute of Health-Research and Leprosy Centre (India)
This study uses molecular biology techniques to develop a laboratory test for early diagnosis of type I en type II reactions in leprosy.
Design of Customized Offloading Devices
Schieffelin Institute of Health Research & Leprosy Centre
Patients suffering from nerve damage caused by leprosy can have a loss of sensation in the feet, which leads to wounds on the sole of the foot. Non-infected simple ulcers are usually treated with total contact casts, which are heavy. This project develops and tests alternative lightweight devices with the help of computer software.
Helminths influences in leprosy
The Leprosy Mission Nepal
This study investigates if worm infection or deworming has any relevance to leprosy clinical care. The research group aims to detect risks and associations between helminth indicators, leprosy indicators and clinical outcomes including leprosy reaction development, severity and duration.
Patient self-monitoring to detect nerve function impairment
Leonard Wood Memorial Center for Leprosy Research (Philippines)
This study aims to assess whether skin lesions can be used as proxy indicaor to detect early signs of nerve function impairment in leprosy.