The St Francis Leprosy Guild celebrates its 125th anniversary this year. Since 1895 the organization has raised over £20 million to enable them to help alleviate the suffering caused by leprosy throughout the world. Recognising the changing landscape of leprosy, and WHO’s 2016-20 strategy of accelerating towards a leprosy-free world, the Guild undertook its own Strategic Review: “A Pilgrimage of Hope” in 2017. Part of that strategic change is a stronger focus on operational work towards supporting active case-finding in the field. The Guild is also committed to fund research of the causes, cure and prevention of leprosy. The LRI is delighted that, as part of their first venture in this direction, they joined the LRI as an Associate Partner as of 1 November 2020. Welcome to the Leprosy Research Initiative.